Assay Detail
Binding
CHEMBL2421737
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Inhibition of human CYP11B2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.42 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365735 | — | — | 1 | 7.55 |
| CHEMBL371430 | — | — | 1 | 7.54 |
| CHEMBL193863 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365735 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL371430 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL193863 | — | IC50 | = | 68.0 | nM | 7.17 |