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Assay Detail

CHEMBL2421972

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAO-A expressed in insect cell microsomes using kynuramine as substrate assessed as formation of 4-hydroxyquinoline by fluorometric method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Subcellular Microsome
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selected furanochalcones as inhibitors of monoamine oxidase.
Robinson SJ, Petzer JP, Petzer A, Bergh JJ, Lourens AC.
Bioorg Med Chem Lett (2013) 23 : 4985 -4989
PubMed 23860591 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.56 5.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2420785 1 5.71
CHEMBL2420783 1 4.82
CHEMBL2420693 1 4.75
CHEMBL1438596 1 4.73
CHEMBL2420794 1 4.72
CHEMBL2420793 1 4.68
CHEMBL2420784 1 4.62
CHEMBL2420790 1 4.54
CHEMBL2420791 1 4.52
CHEMBL2420787 1 4.50
CHEMBL2420694 1 4.39
CHEMBL1269118 1 4.38
CHEMBL2420789 1 4.22
CHEMBL2420792 1 4.21
CHEMBL2420786 1 4.08
CHEMBL1344767 1 4.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2420785 IC50 = 1950.0 nM 5.71
CHEMBL2420783 IC50 = 15000.0 nM 4.82
CHEMBL2420693 IC50 = 18000.0 nM 4.75
CHEMBL1438596 IC50 = 18600.0 nM 4.73
CHEMBL2420794 IC50 = 19200.0 nM 4.72
CHEMBL2420793 IC50 = 21100.0 nM 4.68
CHEMBL2420784 IC50 = 24000.0 nM 4.62
CHEMBL2420790 IC50 = 28600.0 nM 4.54
CHEMBL2420791 IC50 = 30200.0 nM 4.52
CHEMBL2420787 IC50 = 31800.0 nM 4.50
CHEMBL2420694 IC50 = 40900.0 nM 4.39
CHEMBL1269118 IC50 = 41800.0 nM 4.38
CHEMBL2420789 IC50 = 59500.0 nM 4.22
CHEMBL2420792 IC50 = 61600.0 nM 4.21
CHEMBL2420786 IC50 = 83700.0 nM 4.08
CHEMBL1344767 IC50 = 85700.0 nM 4.07