Assay Detail
Binding
CHEMBL2422294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NDM-1 (unknown origin) expressed in Escherichia coli BL21 using meropenem as substrate compound preincubated for 15 min by spectrophotometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Polyketides with New Delhi metallo-β-lactamase 1 inhibitory activity from Penicillium sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.39 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434965 | D-CAPTOPRIL | — | 1 | 5.10 |
| CHEMBL2419350 | — | — | 1 | 4.06 |
| CHEMBL2419349 | — | — | 1 | 4.02 |
| CHEMBL858 | EDETIC ACID | 3.0 | 1 | - |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434965 | D-CAPTOPRIL | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2419350 | — | IC50 | = | 87900.0 | nM | 4.06 |
| CHEMBL2419349 | — | IC50 | = | 94900.0 | nM | 4.02 |
| CHEMBL858 | EDETIC ACID | IC50 | < | 100.0 | nM | - |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 107600.0 | nM | - |