Assay Detail
Binding
CHEMBL2422546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.74 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 9.29 |
| CHEMBL2419769 | — | — | 1 | 8.72 |
| CHEMBL2419771 | — | — | 1 | 8.65 |
| CHEMBL217469 | — | — | 1 | 8.18 |
| CHEMBL3216590 | — | — | 1 | 7.89 |
| CHEMBL2419772 | — | — | 1 | 7.74 |
| CHEMBL2419770 | — | — | 1 | 7.74 |
| CHEMBL3217244 | — | — | 1 | 7.08 |
| CHEMBL2419765 | — | — | 1 | 6.20 |
| CHEMBL2419766 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL2419769 | — | Ki | = | 1.905 | nM | 8.72 |
| CHEMBL2419771 | — | Ki | = | 2.239 | nM | 8.65 |
| CHEMBL217469 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL3216590 | — | Ki | = | 12.88 | nM | 7.89 |
| CHEMBL2419772 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL2419770 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL3217244 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL2419765 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL2419766 | — | Ki | = | 1348.96 | nM | 5.87 |