Assay Detail
Binding
CHEMBL2422548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from human alpha-1A adrenoreceptor expressed in CHO cells after 30 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.10 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 9.39 |
| CHEMBL2419769 | — | — | 1 | 9.31 |
| CHEMBL217469 | — | — | 1 | 8.80 |
| CHEMBL2419771 | — | — | 1 | 8.70 |
| CHEMBL3216590 | — | — | 1 | 8.42 |
| CHEMBL2419770 | — | — | 1 | 8.04 |
| CHEMBL2419772 | — | — | 1 | 7.77 |
| CHEMBL3217244 | — | — | 1 | 7.50 |
| CHEMBL2419765 | — | — | 1 | 6.75 |
| CHEMBL2419766 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Ki | = | 0.4074 | nM | 9.39 |
| CHEMBL2419769 | — | Ki | = | 0.4898 | nM | 9.31 |
| CHEMBL217469 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL2419771 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL3216590 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL2419770 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL2419772 | — | Ki | = | 16.98 | nM | 7.77 |
| CHEMBL3217244 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL2419765 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL2419766 | — | Ki | = | 436.52 | nM | 6.36 |