Assay Detail
Functional
CHEMBL2422646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H460 cells after 48 hrs
15
Total Activities
12
Compounds Tested
4
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.49 | 6.70 |
| LC50 | 1 | - | - |
| TGI | 1 | - | - |
| GI50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279142 | — | — | 1 | 6.70 |
| CHEMBL2420526 | — | — | 1 | 6.23 |
| CHEMBL2420525 | — | — | 4 | 5.67 |
| CHEMBL2420524 | — | — | 1 | 4.86 |
| CHEMBL299143 | — | — | 1 | 4.77 |
| CHEMBL2420519 | — | — | 1 | 4.72 |
| CHEMBL2420527 | — | — | 1 | - |
| CHEMBL2420520 | — | — | 1 | - |
| CHEMBL2420528 | — | — | 1 | - |
| CHEMBL2420522 | — | — | 1 | - |
| CHEMBL2420523 | — | — | 1 | - |
| CHEMBL2420521 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279142 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2420526 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2420525 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL2420524 | — | IC50 | = | 13890.0 | nM | 4.86 |
| CHEMBL299143 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2420519 | — | IC50 | = | 19130.0 | nM | 4.72 |
| CHEMBL2420527 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2420520 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2420528 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2420522 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2420523 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2420521 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2420525 | — | LC50 | < | 100000.0 | nM | - |
| CHEMBL2420525 | — | TGI | < | 100000.0 | nM | - |
| CHEMBL2420525 | — | GI50 | = | 323.59 | nM | - |