Assay Detail
Binding
CHEMBL2422667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selectivity data: assessment, predictions, concordance, and implications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.87 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 8.30 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 8.00 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477772 | PAZOPANIB | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL101253 | VATALANIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 50.12 | nM | 7.30 |