Assay Detail
Functional
CHEMBL2423364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human DOR expressed in HN9.10 cell membranes by [35S]GTPgammaS binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.14 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419538 | — | — | 1 | 9.59 |
| CHEMBL2419542 | — | — | 1 | 8.96 |
| CHEMBL2419537 | — | — | 1 | 8.60 |
| CHEMBL2419541 | — | — | 1 | 8.32 |
| CHEMBL2419539 | — | — | 1 | 8.26 |
| CHEMBL2419544 | — | — | 1 | 7.57 |
| CHEMBL2419543 | — | — | 1 | 7.12 |
| CHEMBL2419540 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419538 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL2419542 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2419537 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2419541 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2419539 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2419544 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2419543 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2419540 | — | EC50 | = | 190.0 | nM | 6.72 |