Assay Detail
Binding
CHEMBL2423498
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Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.71 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2417616 | — | — | 1 | 9.30 |
| CHEMBL2417637 | — | — | 1 | 7.72 |
| CHEMBL2417635 | — | — | 1 | 7.64 |
| CHEMBL2417621 | — | — | 1 | 7.60 |
| CHEMBL2417614 | — | — | 1 | 7.60 |
| CHEMBL2417622 | — | — | 1 | 7.55 |
| CHEMBL2417626 | — | — | 1 | 7.51 |
| CHEMBL2417553 | — | — | 1 | 7.48 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.38 |
| CHEMBL2417623 | — | — | 1 | 7.13 |
| CHEMBL2417620 | — | — | 1 | 7.04 |
| CHEMBL2417624 | — | — | 1 | 6.96 |
| CHEMBL2417625 | — | — | 1 | 6.82 |
| CHEMBL2417619 | — | — | 1 | 6.70 |
| CHEMBL2417628 | — | — | 1 | 6.66 |
| CHEMBL2417627 | — | — | 1 | 6.56 |
| CHEMBL2417632 | — | — | 1 | 6.52 |
| CHEMBL2417633 | — | — | 1 | 6.49 |
| CHEMBL2417612 | — | — | 1 | 6.38 |
| CHEMBL2417634 | — | — | 1 | 6.21 |
| CHEMBL2011253 | — | — | 1 | 6.18 |
| CHEMBL2417615 | — | — | 1 | 6.08 |
| CHEMBL2417630 | — | — | 1 | 5.99 |
| CHEMBL2011262 | — | — | 1 | 5.99 |
| CHEMBL2417613 | — | — | 1 | 5.95 |
| CHEMBL428780 | — | — | 1 | 5.85 |
| CHEMBL2417617 | — | — | 1 | 5.73 |
| CHEMBL2417638 | — | — | 1 | 5.53 |
| CHEMBL2417636 | — | — | 1 | 5.51 |
| CHEMBL2417629 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2417616 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2417637 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2417635 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2417621 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2417614 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2417622 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2417626 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2417553 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL934 | METYRAPONE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2417623 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2417620 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2417624 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2417625 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2417619 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2417628 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2417627 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL2417632 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL2417633 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL2417612 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL2417634 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL2011253 | — | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL2417615 | — | IC50 | = | 836.0 | nM | 6.08 |
| CHEMBL2417630 | — | IC50 | = | 1025.0 | nM | 5.99 |
| CHEMBL2011262 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL2417613 | — | IC50 | = | 1115.0 | nM | 5.95 |
| CHEMBL428780 | — | IC50 | = | 1423.0 | nM | 5.85 |
| CHEMBL2417617 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL2417638 | — | IC50 | = | 2924.0 | nM | 5.53 |
| CHEMBL2417636 | — | IC50 | = | 3111.0 | nM | 5.51 |
| CHEMBL2417629 | — | IC50 | = | 4539.0 | nM | 5.34 |
| CHEMBL2417631 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2417618 | — | IC50 | > | 5000.0 | nM | - |