Assay Detail
Binding
CHEMBL2423680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His-tagged NAMPT (unknown origin) expressed in Escherichia coli BL21 using nicotinamide as substrate preincubated for 15 mins before substrate addition measured after 30 mins by mass spectrometry-based assay
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 7.52 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2420634 | — | — | 1 | 9.00 |
| CHEMBL2420633 | — | — | 1 | 9.00 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 8.70 |
| CHEMBL2420638 | — | — | 1 | 8.70 |
| CHEMBL2420632 | — | — | 1 | 8.70 |
| CHEMBL2420628 | — | — | 1 | 8.52 |
| CHEMBL2420627 | — | — | 1 | 8.52 |
| CHEMBL2420626 | — | — | 1 | 8.52 |
| CHEMBL2420625 | — | — | 1 | 8.52 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.52 |
| CHEMBL2420637 | — | — | 1 | 8.52 |
| CHEMBL2420629 | — | — | 1 | 8.30 |
| CHEMBL2420651 | — | — | 1 | 8.30 |
| CHEMBL2420624 | — | — | 1 | 8.30 |
| CHEMBL2420631 | — | — | 1 | 8.22 |
| CHEMBL2420659 | — | — | 1 | 8.15 |
| CHEMBL2420622 | — | — | 1 | 8.15 |
| CHEMBL2420620 | — | — | 1 | 8.10 |
| CHEMBL2420630 | — | — | 1 | 8.10 |
| CHEMBL2420661 | — | — | 1 | 8.10 |
| CHEMBL2420647 | — | — | 1 | 8.10 |
| CHEMBL2420649 | — | — | 1 | 8.10 |
| CHEMBL2420670 | — | — | 1 | 8.05 |
| CHEMBL2420619 | — | — | 1 | 8.00 |
| CHEMBL2420658 | — | — | 1 | 7.96 |
| CHEMBL2420646 | — | — | 1 | 7.92 |
| CHEMBL2420623 | — | — | 1 | 7.85 |
| CHEMBL2419504 | — | — | 1 | 7.82 |
| CHEMBL2420650 | — | — | 1 | 7.80 |
| CHEMBL2420618 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2420634 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2420633 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2420638 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420632 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL17289 | CHS-828 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420628 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420627 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420626 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420625 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420637 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420629 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2420651 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2420624 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2420631 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2420659 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2420622 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2420620 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2420630 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2420661 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2420647 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2420649 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2420670 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2420619 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2420658 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2420646 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2420623 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2419504 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2420650 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2420618 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2420667 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2420621 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2420648 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2420666 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2419503 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2420664 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2420657 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2420645 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2420644 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2420656 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2420639 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2420660 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2420663 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2420665 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2420640 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2420662 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2420654 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2420642 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2420672 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2420673 | — | IC50 | = | 1000.0 | nM | 6.00 |