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Assay Detail

CHEMBL2423802

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human dopamine D4 receptor by radioligand binding assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(4) dopamine receptor (CHEMBL219)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of highly potent and selective D4 ligands by interactive SAR study.
Abdelfattah MA, Lehmann J, Abadi AH.
Bioorg Med Chem Lett (2013) 23 : 5077 -5081
PubMed 23920439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.93 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2420894 1 10.52
CHEMBL2420779 1 9.15
CHEMBL2420781 1 8.70
CHEMBL2420892 1 8.52
CHEMBL310843 1 8.51
CHEMBL2420773 1 8.41
CHEMBL2420780 1 8.36
CHEMBL2420890 1 8.35
CHEMBL2420895 1 8.21
CHEMBL2420774 1 8.13
CHEMBL2420893 1 7.96
CHEMBL2420891 1 7.65
CHEMBL2420782 1 7.51
CHEMBL2420772 1 7.30
CHEMBL2420771 1 7.28
CHEMBL2420770 1 7.24
CHEMBL2420769 1 7.19
CHEMBL2420777 1 7.11
CHEMBL2420775 1 6.98
CHEMBL2420778 1 6.82
CHEMBL2420776 1 6.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2420894 Ki = 0.03 nM 10.52
CHEMBL2420779 Ki = 0.7 nM 9.15
CHEMBL2420781 Ki = 2.0 nM 8.70
CHEMBL2420892 Ki = 3.0 nM 8.52
CHEMBL310843 Ki = 3.1 nM 8.51
CHEMBL2420773 Ki = 3.9 nM 8.41
CHEMBL2420780 Ki = 4.4 nM 8.36
CHEMBL2420890 Ki = 4.5 nM 8.35
CHEMBL2420895 Ki = 6.2 nM 8.21
CHEMBL2420774 Ki = 7.4 nM 8.13
CHEMBL2420893 Ki = 11.0 nM 7.96
CHEMBL2420891 Ki = 22.5 nM 7.65
CHEMBL2420782 Ki = 31.0 nM 7.51
CHEMBL2420772 Ki = 49.9 nM 7.30
CHEMBL2420771 Ki = 52.0 nM 7.28
CHEMBL2420770 Ki = 57.0 nM 7.24
CHEMBL2420769 Ki = 65.0 nM 7.19
CHEMBL2420777 Ki = 78.0 nM 7.11
CHEMBL2420775 Ki = 105.0 nM 6.98
CHEMBL2420778 Ki = 152.0 nM 6.82
CHEMBL2420776 Ki = 214.0 nM 6.67