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Assay Detail

CHEMBL2423873

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Functional
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of amino analogs of Ludartin: potent and selective cytotoxic agents.
Lone SH, Bhat KA, Shakeel-u-Rehman, Majeed R, Hamid A, Khuroo MA.
Bioorg Med Chem Lett (2013) 23 : 4931 -4934
PubMed 23886685 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.85 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2419017 1 5.58
CHEMBL1097764 LUDARTIN 1 5.13
CHEMBL2419009 1 4.77
CHEMBL2419005 1 4.66
CHEMBL2419014 1 4.50
CHEMBL2419016 1 4.46
CHEMBL2419013 1 -
CHEMBL2419012 1 -
CHEMBL2419011 1 -
CHEMBL2419010 1 -
CHEMBL2419008 1 -
CHEMBL2419007 1 -
CHEMBL2419006 1 -
CHEMBL2419004 1 -
CHEMBL2419015 1 -
CHEMBL2419002 1 -
CHEMBL2419001 1 -
CHEMBL2419003 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2419017 IC50 = 2600.0 nM 5.58
CHEMBL1097764 LUDARTIN IC50 = 7400.0 nM 5.13
CHEMBL2419009 IC50 = 17000.0 nM 4.77
CHEMBL2419005 IC50 = 22000.0 nM 4.66
CHEMBL2419014 IC50 = 32000.0 nM 4.50
CHEMBL2419016 IC50 = 35000.0 nM 4.46
CHEMBL2419013 IC50 - -
CHEMBL2419012 IC50 - -
CHEMBL2419011 IC50 - -
CHEMBL2419010 IC50 - -
CHEMBL2419008 IC50 - -
CHEMBL2419007 IC50 - -
CHEMBL2419006 IC50 - -
CHEMBL2419004 IC50 - -
CHEMBL2419015 IC50 - -
CHEMBL2419002 IC50 - -
CHEMBL2419001 IC50 - -
CHEMBL2419003 IC50 - -