Assay Detail
Functional
CHEMBL2423977
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Chemosensitization of human SNB19 cells expressing MGMT after 5 days by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNB-19 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.04 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419260 | — | — | 1 | 5.16 |
| CHEMBL2419258 | — | — | 1 | 4.92 |
| CHEMBL2419254 | — | — | 1 | - |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419260 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2419258 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2419254 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | > | 250000.0 | nM | - |