Assay Detail
Binding
CHEMBL2424293
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Inhibition of HDAC6 (unknown origin)
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.46 | 7.68 |
| Kd | 1 | 4.97 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178456 | — | — | 1 | 7.68 |
| CHEMBL227118 | — | — | 1 | 7.14 |
| CHEMBL2417783 | — | — | 1 | 6.58 |
| CHEMBL2417784 | — | — | 1 | 6.55 |
| CHEMBL2417785 | — | — | 1 | 5.40 |
| CHEMBL2417786 | — | — | 1 | 5.39 |
| CHEMBL94394 | BUFEXAMAC | 4.0 | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178456 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL227118 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2417783 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2417784 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2417785 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL2417786 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL94394 | BUFEXAMAC | Kd | = | 10700.0 | nM | 4.97 |