Assay Detail
Binding
CHEMBL2424295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin)
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.04 | 6.24 |
| Kd | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227118 | — | — | 1 | 6.24 |
| CHEMBL178456 | — | — | 1 | 5.49 |
| CHEMBL2417783 | — | — | 1 | 5.24 |
| CHEMBL2417786 | — | — | 1 | 4.17 |
| CHEMBL2417785 | — | — | 1 | 4.08 |
| CHEMBL94394 | BUFEXAMAC | 4.0 | 1 | - |
| CHEMBL2417784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227118 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL178456 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL2417783 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2417786 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL2417785 | — | IC50 | = | 82600.0 | nM | 4.08 |
| CHEMBL94394 | BUFEXAMAC | Kd | > | 1000000.0 | nM | - |
| CHEMBL2417784 | — | IC50 | > | 30000.0 | nM | - |