Assay Detail
Binding
CHEMBL2424296
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Inhibition of HDAC2 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.35 | 5.90 |
| Kd | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178456 | — | — | 1 | 5.90 |
| CHEMBL227118 | — | — | 1 | 5.59 |
| CHEMBL2417783 | — | — | 1 | 4.55 |
| CHEMBL94394 | BUFEXAMAC | 4.0 | 1 | - |
| CHEMBL2417784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178456 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL227118 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL2417783 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL94394 | BUFEXAMAC | Kd | > | 1000000.0 | nM | - |
| CHEMBL2417784 | — | IC50 | > | 30000.0 | nM | - |