Assay Detail
Binding
CHEMBL2424424
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Antagonist activity at mu/kappa opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.98 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3038186 | — | — | 1 | 5.98 |
| CHEMBL571492 | — | — | 1 | - |
| CHEMBL538700 | — | — | 1 | - |
| CHEMBL3038184 | — | — | 1 | - |
| CHEMBL3038183 | — | — | 1 | - |
| CHEMBL3038182 | — | — | 1 | - |
| CHEMBL555206 | — | — | 1 | - |
| CHEMBL191751 | — | — | 1 | - |
| CHEMBL3038187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3038186 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL571492 | — | IC50 | - | — | - | |
| CHEMBL538700 | — | IC50 | - | — | - | |
| CHEMBL3038184 | — | IC50 | - | — | - | |
| CHEMBL3038183 | — | IC50 | - | — | - | |
| CHEMBL3038182 | — | IC50 | - | — | - | |
| CHEMBL555206 | — | IC50 | - | — | - | |
| CHEMBL191751 | — | IC50 | - | — | - | |
| CHEMBL3038187 | — | IC50 | - | — | - |