Assay Detail
Binding
CHEMBL2424458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at OX2 receptor (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.74 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2413367 | — | — | 1 | 6.38 |
| CHEMBL455136 | ALMOREXANT | 3.0 | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2413367 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL455136 | ALMOREXANT | IC50 | = | 8100.0 | nM | 5.09 |