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Assay Detail

CHEMBL2426941

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MCF-10A
Confidence 1 — Organism
Curated By Autocuration

Target

MCF-10A (CHEMBL614321)
Type CELL-LINE
Organism Homo sapiens

Publication

Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz.
Qin JJ, Jin HZ, Huang Y, Zhang SD, Shan L, Voruganti S, Nag S, Wang W, Zhang WD, Zhang R.
Eur J Med Chem (2013) 68 : 473 -481
PubMed 24044895 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.72 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 5.55
CHEMBL486997 BIGELOVIN 1 4.58
CHEMBL2426506 1 4.58
CHEMBL2426512 1 4.55
CHEMBL2426504 DEACETYLOVATIFOLIN 1 4.34
CHEMBL1911136 1 -
CHEMBL2426503 1 -
CHEMBL1911142 INUCHINENOLIDE B 1 -
CHEMBL2426502 1 -
CHEMBL2426501 1 -
CHEMBL2426510 1 -
CHEMBL2426509 1 -
CHEMBL2426508 1 -
CHEMBL2332643 1 -
CHEMBL2426505 1 -
CHEMBL2426511 1 -
CHEMBL428647 PACLITAXEL 4.0 1 -
CHEMBL2426507 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 2800.0 nM 5.55
CHEMBL486997 BIGELOVIN IC50 = 26000.0 nM 4.58
CHEMBL2426506 IC50 = 26400.0 nM 4.58
CHEMBL2426512 IC50 = 27900.0 nM 4.55
CHEMBL2426504 DEACETYLOVATIFOLIN IC50 = 45700.0 nM 4.34
CHEMBL1911136 IC50 > 50000.0 nM -
CHEMBL2426503 IC50 > 50000.0 nM -
CHEMBL1911142 INUCHINENOLIDE B IC50 > 50000.0 nM -
CHEMBL2426502 IC50 > 50000.0 nM -
CHEMBL2426501 IC50 > 50000.0 nM -
CHEMBL2426510 IC50 > 50000.0 nM -
CHEMBL2426509 IC50 > 50000.0 nM -
CHEMBL2426508 IC50 > 50000.0 nM -
CHEMBL2332643 IC50 > 50000.0 nM -
CHEMBL2426505 IC50 > 50000.0 nM -
CHEMBL2426511 IC50 > 50000.0 nM -
CHEMBL428647 PACLITAXEL IC50 = 427000.0 nM -
CHEMBL2426507 IC50 > 50000.0 nM -