Assay Detail
Binding
CHEMBL2426985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CDK5/p25 (unknown origin) expressed in Escherichia coli using [gamma-33P]ATP after 30 mins
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.61 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425487 | — | — | 2 | 7.62 |
| CHEMBL301226 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425487 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL301226 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2425487 | — | IC50 | >= | 10000.0 | nM | - |