Assay Detail
Functional
CHEMBL2427062
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Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.57 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2424901 | — | — | 1 | 5.11 |
| CHEMBL2424925 | — | — | 1 | 4.93 |
| CHEMBL2424900 | — | — | 1 | 4.90 |
| CHEMBL362672 | MANSONONE E | — | 1 | 4.80 |
| CHEMBL2424904 | — | — | 1 | 4.79 |
| CHEMBL2424924 | — | — | 1 | 4.78 |
| CHEMBL2424913 | — | — | 1 | 4.77 |
| CHEMBL2424912 | — | — | 1 | 4.75 |
| CHEMBL2424911 | — | — | 1 | 4.61 |
| CHEMBL2424923 | — | — | 1 | 4.58 |
| CHEMBL2424902 | — | — | 1 | 4.57 |
| CHEMBL2424910 | — | — | 1 | 4.54 |
| CHEMBL2424916 | — | — | 1 | 4.54 |
| CHEMBL2424920 | — | — | 1 | 4.52 |
| CHEMBL2424921 | — | — | 1 | 4.51 |
| CHEMBL2424909 | — | — | 1 | 4.48 |
| CHEMBL2424914 | — | — | 1 | 4.39 |
| CHEMBL2424922 | — | — | 1 | 4.37 |
| CHEMBL2424903 | — | — | 1 | 4.37 |
| CHEMBL2424906 | — | — | 1 | 4.32 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.20 |
| CHEMBL2424907 | — | — | 1 | 4.17 |
| CHEMBL2424908 | — | — | 1 | 4.15 |
| CHEMBL2424905 | — | — | 1 | - |
| CHEMBL2424926 | — | — | 1 | - |
| CHEMBL2424927 | — | — | 1 | - |
| CHEMBL2424915 | — | — | 1 | - |
| CHEMBL2424917 | — | — | 1 | - |
| CHEMBL2424918 | — | — | 1 | - |
| CHEMBL2424919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2424901 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL2424925 | — | IC50 | = | 11750.0 | nM | 4.93 |
| CHEMBL2424900 | — | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL362672 | MANSONONE E | IC50 | = | 15720.0 | nM | 4.80 |
| CHEMBL2424904 | — | IC50 | = | 16210.0 | nM | 4.79 |
| CHEMBL2424924 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL2424913 | — | IC50 | = | 16920.0 | nM | 4.77 |
| CHEMBL2424912 | — | IC50 | = | 17990.0 | nM | 4.75 |
| CHEMBL2424911 | — | IC50 | = | 24370.0 | nM | 4.61 |
| CHEMBL2424923 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL2424902 | — | IC50 | = | 26670.0 | nM | 4.57 |
| CHEMBL2424910 | — | IC50 | = | 29130.0 | nM | 4.54 |
| CHEMBL2424916 | — | IC50 | = | 28940.0 | nM | 4.54 |
| CHEMBL2424920 | — | IC50 | = | 30170.0 | nM | 4.52 |
| CHEMBL2424921 | — | IC50 | = | 30590.0 | nM | 4.51 |
| CHEMBL2424909 | — | IC50 | = | 32840.0 | nM | 4.48 |
| CHEMBL2424914 | — | IC50 | = | 40860.0 | nM | 4.39 |
| CHEMBL2424922 | — | IC50 | = | 42850.0 | nM | 4.37 |
| CHEMBL2424903 | — | IC50 | = | 43070.0 | nM | 4.37 |
| CHEMBL2424906 | — | IC50 | = | 48390.0 | nM | 4.32 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 63710.0 | nM | 4.20 |
| CHEMBL2424907 | — | IC50 | = | 67380.0 | nM | 4.17 |
| CHEMBL2424908 | — | IC50 | = | 70160.0 | nM | 4.15 |
| CHEMBL2424905 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2424926 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2424927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2424915 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2424917 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2424918 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2424919 | — | IC50 | > | 50000.0 | nM | - |