Assay Detail
Functional
CHEMBL2427128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Increase of synaptic activity in rat PC12 cells after 5 days by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.13 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425970 | — | — | 1 | 5.54 |
| CHEMBL2425968 | — | — | 1 | 5.48 |
| CHEMBL2425971 | — | — | 1 | 5.44 |
| CHEMBL2425964 | — | — | 1 | 5.28 |
| CHEMBL2425958 | — | — | 1 | 5.19 |
| CHEMBL2425952 | — | — | 1 | 5.17 |
| CHEMBL2425962 | — | — | 1 | 5.16 |
| CHEMBL2425961 | — | — | 1 | 5.14 |
| CHEMBL2425957 | — | — | 1 | 5.09 |
| CHEMBL2425966 | — | — | 1 | 4.86 |
| CHEMBL2425960 | — | — | 1 | 4.84 |
| CHEMBL2425955 | — | — | 1 | 4.80 |
| CHEMBL2425965 | — | — | 1 | 4.69 |
| CHEMBL2425963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425970 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2425968 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2425971 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2425964 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2425958 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2425952 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2425962 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2425961 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2425957 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL2425966 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL2425960 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL2425955 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL2425965 | — | EC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL2425963 | — | EC50 | - | — | - |