Assay Detail
Binding
CHEMBL2427135
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Inhibition of human recombinant HDAC11 expressed in baculovirus/sf9 cells using RHKKAc as substrate
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.67 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.76 |
| CHEMBL2425970 | — | — | 1 | 6.18 |
| CHEMBL2425960 | — | — | 1 | 6.14 |
| CHEMBL2425959 | — | — | 1 | 5.92 |
| CHEMBL2425971 | — | — | 1 | 5.88 |
| CHEMBL2425955 | — | — | 1 | 5.87 |
| CHEMBL2425957 | — | — | 1 | 5.61 |
| CHEMBL2425961 | — | — | 1 | 5.53 |
| CHEMBL2425967 | — | — | 1 | 5.43 |
| CHEMBL2425965 | — | — | 1 | 5.41 |
| CHEMBL2425958 | — | — | 1 | 5.39 |
| CHEMBL2425966 | — | — | 1 | 5.37 |
| CHEMBL2425968 | — | — | 1 | 5.33 |
| CHEMBL2425954 | — | — | 1 | 5.28 |
| CHEMBL2425962 | — | — | 1 | 5.25 |
| CHEMBL2425952 | — | — | 1 | 4.43 |
| CHEMBL2425964 | — | — | 1 | - |
| CHEMBL2425963 | — | — | 1 | - |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | - |
| CHEMBL2425956 | — | — | 1 | - |
| CHEMBL2425969 | — | — | 1 | - |
| CHEMBL2425953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL2425970 | — | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL2425960 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2425959 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL2425971 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2425955 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2425957 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL2425961 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL2425967 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL2425965 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL2425958 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL2425966 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL2425968 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL2425954 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL2425962 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL2425952 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL2425964 | — | IC50 | - | — | - | |
| CHEMBL2425963 | — | IC50 | - | — | - | |
| CHEMBL2018302 | TUBASTATIN A | IC50 | > | 30000.0 | nM | - |
| CHEMBL2425956 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2425969 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2425953 | — | IC50 | > | 10000.0 | nM | - |