Assay Detail
Binding
CHEMBL2427136
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Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.47 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.05 |
| CHEMBL2425968 | — | — | 1 | 8.10 |
| CHEMBL2425971 | — | — | 1 | 8.05 |
| CHEMBL2425961 | — | — | 1 | 7.96 |
| CHEMBL2425970 | — | — | 1 | 7.96 |
| CHEMBL2425964 | — | — | 1 | 7.89 |
| CHEMBL2425967 | — | — | 1 | 7.85 |
| CHEMBL2425959 | — | — | 1 | 7.82 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.82 |
| CHEMBL2425957 | — | — | 1 | 7.62 |
| CHEMBL2425958 | — | — | 1 | 7.54 |
| CHEMBL2425954 | — | — | 1 | 7.50 |
| CHEMBL2425962 | — | — | 1 | 7.48 |
| CHEMBL2425960 | — | — | 1 | 7.46 |
| CHEMBL2425963 | — | — | 1 | 7.39 |
| CHEMBL2425965 | — | — | 1 | 7.39 |
| CHEMBL2425966 | — | — | 1 | 7.37 |
| CHEMBL2425952 | — | — | 1 | 7.10 |
| CHEMBL2425955 | — | — | 1 | 7.06 |
| CHEMBL2425956 | — | — | 1 | 6.16 |
| CHEMBL2425969 | — | — | 1 | 6.13 |
| CHEMBL2425953 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2425968 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2425971 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2425961 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2425970 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2425964 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2425967 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2425959 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2425957 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2425958 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2425954 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2425962 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2425960 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2425963 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2425965 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2425966 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2425952 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2425955 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2425956 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2425969 | — | IC50 | = | 747.0 | nM | 6.13 |
| CHEMBL2425953 | — | IC50 | = | 1920.0 | nM | 5.72 |