Assay Detail
Binding
CHEMBL2427138
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Inhibition of human recombinant HDAC8 expressed in baculovirus/sf9 cells using RHKAcKAc as substrate
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.14 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425970 | — | — | 1 | 7.00 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.89 |
| CHEMBL2425971 | — | — | 1 | 6.76 |
| CHEMBL2425952 | — | — | 1 | 6.55 |
| CHEMBL2425956 | — | — | 1 | 6.38 |
| CHEMBL2425965 | — | — | 1 | 6.23 |
| CHEMBL2425960 | — | — | 1 | 6.22 |
| CHEMBL2425954 | — | — | 1 | 6.21 |
| CHEMBL2425968 | — | — | 1 | 6.12 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 6.07 |
| CHEMBL2425966 | — | — | 1 | 6.05 |
| CHEMBL2425953 | — | — | 1 | 5.97 |
| CHEMBL2425961 | — | — | 1 | 5.93 |
| CHEMBL2425957 | — | — | 1 | 5.90 |
| CHEMBL2425962 | — | — | 1 | 5.88 |
| CHEMBL2425967 | — | — | 1 | 5.85 |
| CHEMBL2425959 | — | — | 1 | 5.80 |
| CHEMBL2425958 | — | — | 1 | 5.76 |
| CHEMBL2425969 | — | — | 1 | 5.73 |
| CHEMBL2425955 | — | — | 1 | 5.41 |
| CHEMBL2425963 | — | — | 1 | - |
| CHEMBL2425964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425970 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL2425971 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL2425952 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL2425956 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2425965 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL2425960 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2425954 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL2425968 | — | IC50 | = | 766.0 | nM | 6.12 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL2425966 | — | IC50 | = | 891.0 | nM | 6.05 |
| CHEMBL2425953 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL2425961 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL2425957 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL2425962 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL2425967 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2425959 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL2425958 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2425969 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL2425955 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL2425963 | — | IC50 | - | — | - | |
| CHEMBL2425964 | — | IC50 | - | — | - |