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Assay Detail

CHEMBL2427556

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human adenosine A3 receptor
ChEMBL ↗
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A3 (CHEMBL256) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Descriptors requirement for QSAR analysis of pyrazolo-triazolo-pyrimidine derivative as human A3 receptor antagonists: design of novel furan derivatives and validation by docking
Prajapati LM, Patel JR, Parmar VK
Med Chem Res (2013) : 1 -10
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 80 8.61 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145767 — — 1 9.85
CHEMBL352796 — — 1 9.74
CHEMBL352073 — — 1 9.70
CHEMBL165224 — — 1 9.62
CHEMBL165083 — — 1 9.57
CHEMBL165778 — — 1 9.54
CHEMBL167753 — — 1 9.54
CHEMBL166301 — — 1 9.52
CHEMBL352345 — — 1 9.52
CHEMBL330286 — — 1 9.49
CHEMBL572765 — — 1 9.47
CHEMBL164905 — — 1 9.47
CHEMBL165560 — — 1 9.47
CHEMBL165600 — — 1 9.43
CHEMBL351075 — — 1 9.40
CHEMBL350261 — — 1 9.40
CHEMBL424161 — — 1 9.37
CHEMBL354161 — — 1 9.37
CHEMBL350205 — — 1 9.35
CHEMBL348925 — — 1 9.34
CHEMBL304726 — — 1 9.32
CHEMBL142562 — — 1 9.30
CHEMBL352192 — — 1 9.30
CHEMBL164509 — — 1 9.29
CHEMBL167915 — — 1 9.26
CHEMBL164647 — — 1 9.25
CHEMBL349611 — — 1 9.24
CHEMBL65271 — — 1 9.22
CHEMBL164325 — — 1 9.22
CHEMBL423934 — — 1 9.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145767 — Ki = 0.14 nM 9.85
CHEMBL352796 — Ki = 0.1799 nM 9.74
CHEMBL352073 — Ki = 0.2 nM 9.70
CHEMBL165224 — Ki = 0.2399 nM 9.62
CHEMBL165083 — Ki = 0.2698 nM 9.57
CHEMBL165778 — Ki = 0.2897 nM 9.54
CHEMBL167753 — Ki = 0.2897 nM 9.54
CHEMBL166301 — Ki = 0.2999 nM 9.52
CHEMBL352345 — Ki = 0.2999 nM 9.52
CHEMBL330286 — Ki = 0.3199 nM 9.49
CHEMBL572765 — Ki = 0.3396 nM 9.47
CHEMBL164905 — Ki = 0.3396 nM 9.47
CHEMBL165560 — Ki = 0.3396 nM 9.47
CHEMBL165600 — Ki = 0.3698 nM 9.43
CHEMBL350261 — Ki = 0.3999 nM 9.40
CHEMBL351075 — Ki = 0.3999 nM 9.40
CHEMBL424161 — Ki = 0.4295 nM 9.37
CHEMBL354161 — Ki = 0.4295 nM 9.37
CHEMBL350205 — Ki = 0.4498 nM 9.35
CHEMBL348925 — Ki = 0.4603 nM 9.34
CHEMBL304726 — Ki = 0.4797 nM 9.32
CHEMBL142562 — Ki = 0.5 nM 9.30
CHEMBL352192 — Ki = 0.5 nM 9.30
CHEMBL164509 — Ki = 0.5105 nM 9.29
CHEMBL167915 — Ki = 0.5495 nM 9.26
CHEMBL164647 — Ki = 0.5598 nM 9.25
CHEMBL349611 — Ki = 0.5702 nM 9.24
CHEMBL65271 — Ki = 0.5998 nM 9.22
CHEMBL164325 — Ki = 0.5998 nM 9.22
CHEMBL423934 — Ki = 0.5998 nM 9.22
CHEMBL165910 — Ki = 0.6501 nM 9.19
CHEMBL350042 — Ki = 0.7096 nM 9.15
CHEMBL351211 — Ki = 0.6998 nM 9.15
CHEMBL349954 — Ki = 0.7194 nM 9.14
CHEMBL164686 — Ki = 0.7396 nM 9.13
CHEMBL357663 — Ki = 0.7998 nM 9.10
CHEMBL302765 — Ki = 0.7998 nM 9.10
CHEMBL164992 — Ki = 0.7998 nM 9.10
CHEMBL165620 — Ki = 0.7998 nM 9.10
CHEMBL341376 — Ki = 0.8091 nM 9.09
CHEMBL355415 — Ki = 0.8091 nM 9.09
CHEMBL164685 — Ki = 0.859 nM 9.07
CHEMBL164381 — Ki = 0.859 nM 9.07
CHEMBL349716 — Ki = 0.859 nM 9.07
CHEMBL138332 — Ki = 0.9099 nM 9.04
CHEMBL164281 — Ki = 0.9099 nM 9.04
CHEMBL350830 — Ki = 0.9099 nM 9.04
CHEMBL165044 — Ki = 0.9705 nM 9.01
CHEMBL349464 — Ki = 1.009 nM 9.00
CHEMBL362190 — Ki = 1.009 nM 9.00