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Assay Detail

CHEMBL2428935

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Functional
Antiparasitic activity against Toxoplasma gondii expressing beta-galactosidase infected in HFF assessed as parasite growth inhibition after 72 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Confidence 1 — Organism
Curated By Autocuration

Target

Toxoplasma gondii (CHEMBL612888)
Type ORGANISM
Organism Toxoplasma gondii

Publication

Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii.
Ma CI, Diraviyam K, Maier ME, Sept D, Sibley LD.
J Nat Prod (2013) 76 : 1565 -1572
PubMed 24020843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.28 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2426320 1 6.66
CHEMBL2426325 1 6.50
CHEMBL257166 JASPAMIDE 1 6.47
CHEMBL2426329 1 6.42
CHEMBL2426321 1 6.32
CHEMBL2426322 1 6.29
CHEMBL2426323 1 6.28
CHEMBL2426319 1 6.25
CHEMBL2426328 1 6.22
CHEMBL2426326 1 6.21
CHEMBL2426331 1 6.18
CHEMBL2426324 1 6.16
CHEMBL2426327 1 6.13
CHEMBL2426330 1 5.87
CHEMBL2426332 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2426320 EC50 = 220.0 nM 6.66
CHEMBL2426325 EC50 = 320.0 nM 6.50
CHEMBL257166 JASPAMIDE EC50 = 340.0 nM 6.47
CHEMBL2426329 EC50 = 380.0 nM 6.42
CHEMBL2426321 EC50 = 480.0 nM 6.32
CHEMBL2426322 EC50 = 510.0 nM 6.29
CHEMBL2426323 EC50 = 530.0 nM 6.28
CHEMBL2426319 EC50 = 560.0 nM 6.25
CHEMBL2426328 EC50 = 600.0 nM 6.22
CHEMBL2426326 EC50 = 610.0 nM 6.21
CHEMBL2426331 EC50 = 660.0 nM 6.18
CHEMBL2426324 EC50 = 690.0 nM 6.16
CHEMBL2426327 EC50 = 740.0 nM 6.13
CHEMBL2426330 EC50 = 1340.0 nM 5.87
CHEMBL2426332 EC50 >= 45000.0 nM -