Assay Detail
Binding
CHEMBL2429202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1/Cyclin B (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.51 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425904 | — | — | 1 | 7.15 |
| CHEMBL2425903 | — | — | 1 | 6.85 |
| CHEMBL303958 | — | — | 1 | 5.54 |
| CHEMBL2425902 | — | — | 1 | - |
| CHEMBL2425901 | — | — | 1 | - |
| CHEMBL2425900 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425904 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2425903 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL303958 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2425902 | — | IC50 | - | — | - | |
| CHEMBL2425901 | — | IC50 | - | — | - | |
| CHEMBL2425900 | — | IC50 | - | — | - |