Assay Detail
Binding
CHEMBL2429273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MMP-8 (unknown origin) using 7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 9.07 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425938 | — | — | 1 | 10.30 |
| CHEMBL2425943 | — | — | 1 | 9.70 |
| CHEMBL2425950 | — | — | 1 | 9.70 |
| CHEMBL2425944 | — | — | 1 | 9.52 |
| CHEMBL2425941 | — | — | 1 | 9.52 |
| CHEMBL2425947 | — | — | 1 | 9.40 |
| CHEMBL2425936 | — | — | 1 | 9.40 |
| CHEMBL2425949 | — | — | 1 | 9.30 |
| CHEMBL2425939 | — | — | 1 | 9.15 |
| CHEMBL2425932 | — | — | 1 | 9.05 |
| CHEMBL2425948 | — | — | 1 | 9.00 |
| CHEMBL2425930 | — | — | 1 | 9.00 |
| CHEMBL2425931 | — | — | 1 | 9.00 |
| CHEMBL2425935 | — | — | 1 | 9.00 |
| CHEMBL2425946 | — | — | 1 | 8.70 |
| CHEMBL2425933 | — | — | 1 | 8.70 |
| CHEMBL2425942 | — | — | 1 | 8.70 |
| CHEMBL2425934 | — | — | 1 | 8.40 |
| CHEMBL2425940 | — | — | 1 | 8.30 |
| CHEMBL2425937 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425938 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL2425943 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2425950 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2425944 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2425941 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2425947 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2425936 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2425949 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2425939 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2425932 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2425948 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2425930 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2425931 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2425935 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2425946 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2425933 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2425942 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2425934 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2425940 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2425937 | — | IC50 | = | 35.0 | nM | 7.46 |