Assay Detail
Binding
CHEMBL2429341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human JNK2 assessed as inhibition of GST-tagged ATF2 (19 to 96) phosphorylation incubated for 10 mins prior to substrate addition measured after 30 mins by scintillation counting analysis in presence of [gamma-33P]-ATP
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.83 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425635 | — | — | 1 | 7.68 |
| CHEMBL2390974 | — | — | 1 | 7.62 |
| CHEMBL2425634 | — | — | 1 | 7.57 |
| CHEMBL2425630 | — | — | 1 | 7.55 |
| CHEMBL2425629 | — | — | 1 | 7.33 |
| CHEMBL2425631 | — | — | 1 | 7.29 |
| CHEMBL2425633 | — | — | 1 | 7.24 |
| CHEMBL2425632 | — | — | 1 | 7.19 |
| CHEMBL2425628 | — | — | 1 | 7.18 |
| CHEMBL2425653 | — | — | 1 | 7.12 |
| CHEMBL2425639 | — | — | 1 | 7.10 |
| CHEMBL2425655 | — | — | 1 | 7.01 |
| CHEMBL2425654 | — | — | 1 | 6.96 |
| CHEMBL2425640 | — | — | 1 | 6.86 |
| CHEMBL2425636 | — | — | 1 | 6.82 |
| CHEMBL2425652 | — | — | 1 | 6.77 |
| CHEMBL2425649 | — | — | 1 | 6.75 |
| CHEMBL2425641 | — | — | 1 | 6.75 |
| CHEMBL2425638 | — | — | 1 | 6.71 |
| CHEMBL2425651 | — | — | 1 | 6.64 |
| CHEMBL2425637 | — | — | 1 | 6.61 |
| CHEMBL2425648 | — | — | 1 | 6.60 |
| CHEMBL2425645 | — | — | 1 | 6.46 |
| CHEMBL2425646 | — | — | 1 | 6.44 |
| CHEMBL2425656 | — | — | 1 | 6.41 |
| CHEMBL2425650 | — | — | 1 | 6.40 |
| CHEMBL2425644 | — | — | 1 | 6.19 |
| CHEMBL2425642 | — | — | 1 | 6.14 |
| CHEMBL2425647 | — | — | 1 | 5.92 |
| CHEMBL2425643 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425635 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2390974 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2425634 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2425630 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2425629 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2425631 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2425633 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2425632 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL2425628 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2425653 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2425639 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2425655 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2425654 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2425640 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2425636 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2425652 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2425649 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2425641 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL2425638 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL2425651 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2425637 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL2425648 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2425645 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2425646 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2425656 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2425650 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2425644 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2425642 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2425647 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2425643 | — | IC50 | = | 2900.0 | nM | 5.54 |