Assay Detail
Binding
CHEMBL2429352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CREB-KID/CBP-KIX domain interaction (unknown origin) after 20 hrs by luciferase reporter gene assay
8
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.66 | 6.77 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2426724 | — | — | 1 | 6.77 |
| CHEMBL505670 | — | — | 2 | 6.44 |
| CHEMBL2426721 | — | — | 1 | 6.39 |
| CHEMBL2426722 | — | — | 1 | 5.15 |
| CHEMBL2426725 | — | — | 1 | 4.88 |
| CHEMBL2426723 | — | — | 1 | 4.30 |
| CHEMBL2426726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2426724 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL505670 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2426721 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2426722 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL2426725 | — | IC50 | = | 13060.0 | nM | 4.88 |
| CHEMBL2426723 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2426726 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL505670 | — | Inhibition | - | % | - |