Assay Detail

CHEMBL2429558

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Functional

Cytotoxicity against human p53-deficient Saos2 cells assessed as cell survival after 48 hrs by trypan blue exclusion assay

ChEMBL ↗

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Target

SAOS-2 (CHEMBL614894) ↗

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SAOS-2 (CHEMBL614894) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SAOS-2

CHEMBL614894

Anchored from Assay target.

Protein identity SAOS-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SAOS-2
Confidence	1 — Organism
Curated By	Autocuration

Target

SAOS-2 (CHEMBL614894) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthetic polyamines activating autophagy: effects on cancer cell death.

Minarini A, Zini M, Milelli A, Tumiatti V, Marchetti C, Nicolini B, Falconi M, Farruggia G, Cappadone C, Stefanelli C.
Eur J Med Chem (2013) 67 : 359 -366
PubMed 23887056 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.52	6.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2398522	—	—	1	6.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2398522	—	IC50	=	300.0	nM	6.52