Assay Detail
Binding
CHEMBL2429676
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Inhibition of dCK in human CCRF-CEM cells assessed as inhibition of tritiated deoxycytidine [3H]-dC uptake
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.36 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2426563 | — | — | 1 | 8.97 |
| CHEMBL2426570 | — | — | 1 | 8.94 |
| CHEMBL2426573 | — | — | 1 | 8.84 |
| CHEMBL2426569 | — | — | 1 | 8.81 |
| CHEMBL2426562 | — | — | 1 | 8.61 |
| CHEMBL2426567 | — | — | 1 | 8.59 |
| CHEMBL2426564 | — | — | 1 | 8.55 |
| CHEMBL2426572 | — | — | 1 | 8.54 |
| CHEMBL2426571 | — | — | 1 | 8.54 |
| CHEMBL2426558 | — | — | 1 | 8.52 |
| CHEMBL2426574 | — | — | 1 | 8.31 |
| CHEMBL2426598 | — | — | 1 | 8.15 |
| CHEMBL2426566 | — | — | 1 | 8.10 |
| CHEMBL2426557 | — | — | 1 | 7.96 |
| CHEMBL2426565 | — | — | 1 | 7.94 |
| CHEMBL2426588 | — | — | 1 | 7.75 |
| CHEMBL2426568 | — | — | 1 | 7.73 |
| CHEMBL2426561 | — | — | 1 | 7.51 |
| CHEMBL2426560 | — | — | 1 | 7.43 |
| CHEMBL2426460 | — | — | 1 | 7.08 |
| CHEMBL2426591 | — | — | 1 | 7.04 |
| CHEMBL2426589 | — | — | 1 | 6.82 |
| CHEMBL2426459 | — | — | 1 | 6.79 |
| CHEMBL2426559 | — | — | 1 | 6.76 |
| CHEMBL2426585 | — | — | 1 | 6.71 |
| CHEMBL2426590 | — | — | 1 | 6.64 |
| CHEMBL2426582 | — | — | 1 | 6.64 |
| CHEMBL2426583 | — | — | 1 | 6.60 |
| CHEMBL2426596 | — | — | 1 | 6.53 |
| CHEMBL2426581 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2426563 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL2426570 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL2426573 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL2426569 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL2426562 | — | IC50 | = | 2.45 | nM | 8.61 |
| CHEMBL2426567 | — | IC50 | = | 2.59 | nM | 8.59 |
| CHEMBL2426564 | — | IC50 | = | 2.83 | nM | 8.55 |
| CHEMBL2426572 | — | IC50 | = | 2.85 | nM | 8.54 |
| CHEMBL2426571 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2426558 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2426574 | — | IC50 | = | 4.89 | nM | 8.31 |
| CHEMBL2426598 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2426566 | — | IC50 | = | 8.01 | nM | 8.10 |
| CHEMBL2426557 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2426565 | — | IC50 | = | 11.58 | nM | 7.94 |
| CHEMBL2426588 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2426568 | — | IC50 | = | 18.62 | nM | 7.73 |
| CHEMBL2426561 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2426560 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2426460 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2426591 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2426589 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2426459 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL2426559 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL2426585 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL2426590 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2426582 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2426583 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL2426596 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL2426581 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL2426593 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL2426594 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL2426592 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL2426597 | — | IC50 | = | 849.0 | nM | 6.07 |
| CHEMBL2426586 | — | IC50 | = | 1041.0 | nM | 5.98 |
| CHEMBL2426595 | — | IC50 | = | 1922.0 | nM | 5.72 |
| CHEMBL2426584 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL2426587 | — | IC50 | = | 2367.0 | nM | 5.63 |