Assay Detail
Binding
CHEMBL2432397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured every 15 secs for 20 mins by fluorimetric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.46 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2337691 | — | — | 1 | 6.51 |
| CHEMBL2431030 | — | — | 1 | 6.23 |
| CHEMBL2431029 | — | — | 1 | 6.20 |
| CHEMBL2431020 | — | — | 1 | 6.05 |
| CHEMBL2431016 | — | — | 1 | 6.03 |
| CHEMBL2431015 | — | — | 1 | 5.80 |
| CHEMBL2431018 | — | — | 1 | 5.77 |
| CHEMBL94715 | — | — | 1 | 5.54 |
| CHEMBL2431017 | — | — | 1 | 5.54 |
| CHEMBL2431031 | — | — | 1 | 5.14 |
| CHEMBL2431028 | — | — | 1 | 4.71 |
| CHEMBL2431025 | — | — | 1 | 4.67 |
| CHEMBL2431027 | — | — | 1 | 4.17 |
| CHEMBL2431032 | — | — | 1 | 4.14 |
| CHEMBL2431019 | — | — | 1 | - |
| CHEMBL2431021 | — | — | 1 | - |
| CHEMBL2431022 | — | — | 1 | - |
| CHEMBL2431023 | — | — | 1 | - |
| CHEMBL2431024 | — | — | 1 | - |
| CHEMBL2431026 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2337691 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2431030 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2431029 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2431020 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2431016 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL2431015 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2431018 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL94715 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2431017 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2431031 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2431028 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL2431025 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL2431027 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL2431032 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL2431019 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL2431021 | — | IC50 | = | 113000.0 | nM | - |
| CHEMBL2431022 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL2431023 | — | IC50 | - | — | - | |
| CHEMBL2431024 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL2431026 | — | IC50 | = | 104000.0 | nM | - |