Assay Detail
Binding
CHEMBL2432398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MMP-2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured every 15 secs for 20 mins by fluorimetric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.05 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431029 | — | — | 1 | 8.92 |
| CHEMBL2431030 | — | — | 1 | 8.52 |
| CHEMBL2337691 | — | — | 1 | 8.42 |
| CHEMBL2431031 | — | — | 1 | 8.12 |
| CHEMBL2431016 | — | — | 1 | 8.11 |
| CHEMBL2431015 | — | — | 1 | 7.82 |
| CHEMBL2431020 | — | — | 1 | 7.75 |
| CHEMBL2431017 | — | — | 1 | 7.70 |
| CHEMBL2431018 | — | — | 1 | 7.39 |
| CHEMBL2431032 | — | — | 1 | 7.32 |
| CHEMBL94715 | — | — | 1 | 6.96 |
| CHEMBL2431028 | — | — | 1 | 6.62 |
| CHEMBL2431019 | — | — | 1 | 6.17 |
| CHEMBL2431025 | — | — | 1 | 5.98 |
| CHEMBL2431027 | — | — | 1 | 5.84 |
| CHEMBL2431021 | — | — | 1 | 5.76 |
| CHEMBL2431022 | — | — | 1 | 5.73 |
| CHEMBL2431024 | — | — | 1 | 5.42 |
| CHEMBL2431026 | — | — | 1 | 5.39 |
| CHEMBL2431023 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431029 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2431030 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2337691 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2431031 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2431016 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL2431015 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2431020 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2431017 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2431018 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2431032 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL94715 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2431028 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2431019 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2431025 | — | IC50 | = | 1045.0 | nM | 5.98 |
| CHEMBL2431027 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL2431021 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2431022 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL2431024 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2431026 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2431023 | — | IC50 | = | 125000.0 | nM | - |