Assay Detail
Functional
CHEMBL2432680
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Antiviral activity against Hepatitis C virus 1b RO-10 expressing NS5B assessed as inhibition of viral replication after 4 days by luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.98 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431365 | — | — | 1 | 8.55 |
| CHEMBL490672 | FILIBUVIR | 3.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431365 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL490672 | FILIBUVIR | EC50 | = | 39.7 | nM | 7.40 |