Assay Detail
Binding
CHEMBL2433122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assay
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.18 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64780 | — | — | 2 | 5.58 |
| CHEMBL2431805 | — | — | 2 | 5.26 |
| CHEMBL16861 | — | — | 2 | 5.15 |
| CHEMBL2431867 | — | — | 2 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64780 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL64780 | — | IC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL2431805 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2431805 | — | IC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL16861 | — | IC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL16861 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2431867 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL2431867 | — | IC50 | = | 19100.0 | nM | 4.72 |