Assay Detail
Binding
CHEMBL2433123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assay
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.11 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431805 | — | — | 2 | 6.32 |
| CHEMBL64780 | — | — | 2 | 5.08 |
| CHEMBL16861 | — | — | 2 | 4.56 |
| CHEMBL2431867 | — | — | 2 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431805 | — | IC50 | = | 478.63 | nM | 6.32 |
| CHEMBL2431805 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL64780 | — | IC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL64780 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL16861 | — | IC50 | = | 27542.29 | nM | 4.56 |
| CHEMBL16861 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL2431867 | — | IC50 | = | 34673.69 | nM | 4.46 |
| CHEMBL2431867 | — | IC50 | = | 34900.0 | nM | 4.46 |