Assay Detail
Binding
CHEMBL2433166
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Inhibition of HDAC6 in human HeLa cells using acetyl tubulin as substrate assessed as Ac-Lys accumulation in nuclear histones after 6 hrs by immunofluorescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.33 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431916 | — | — | 1 | 8.30 |
| CHEMBL2431919 | — | — | 1 | 7.75 |
| CHEMBL2431918 | — | — | 1 | 7.30 |
| CHEMBL2431917 | — | — | 1 | 6.80 |
| CHEMBL2431921 | — | — | 1 | 6.79 |
| CHEMBL2431920 | — | — | 1 | 6.75 |
| CHEMBL2431901 | — | — | 1 | 6.68 |
| CHEMBL2431905 | — | — | 1 | 6.47 |
| CHEMBL2431906 | — | — | 1 | 6.47 |
| CHEMBL2431902 | — | — | 1 | 6.37 |
| CHEMBL2431862 | — | — | 1 | 6.34 |
| CHEMBL2431903 | — | — | 1 | 6.27 |
| CHEMBL2431907 | — | — | 1 | 6.25 |
| CHEMBL2431909 | — | — | 1 | 6.24 |
| CHEMBL2431904 | — | — | 1 | 5.89 |
| CHEMBL2431912 | — | — | 1 | 5.83 |
| CHEMBL2431908 | — | — | 1 | 5.82 |
| CHEMBL2431910 | — | — | 1 | 5.70 |
| CHEMBL2431911 | — | — | 1 | 5.58 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.54 |
| CHEMBL2431914 | — | — | 1 | 5.54 |
| CHEMBL2431915 | — | — | 1 | 5.51 |
| CHEMBL2431913 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431916 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2431919 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2431918 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2431917 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL2431921 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL2431920 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL2431901 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2431905 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2431906 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2431902 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2431862 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2431903 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2431907 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2431909 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2431904 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2431912 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL2431908 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL2431910 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2431911 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL356769 | TUBACIN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2431914 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2431915 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL2431913 | — | IC50 | = | 3680.0 | nM | 5.43 |