Assay Detail
Binding
CHEMBL2433432
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Inhibition of human carbonic anhydrase-12 by stopped flow CO2 hydrase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.62 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL574780 | — | — | 1 | 7.92 |
| CHEMBL573127 | — | — | 1 | 7.68 |
| CHEMBL574782 | — | — | 1 | 7.15 |
| CHEMBL2430111 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL574780 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL573127 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL574782 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2430111 | — | Ki | = | 78.0 | nM | 7.11 |