Assay Detail
Binding
CHEMBL2433433
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Inhibition of human carbonic anhydrase-9 by stopped flow CO2 hydrase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.48 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574780 | — | — | 1 | 7.96 |
| CHEMBL573127 | — | — | 1 | 7.72 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL574782 | — | — | 1 | 7.08 |
| CHEMBL2430111 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574780 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL573127 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL574782 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL2430111 | — | Ki | = | 96.0 | nM | 7.02 |