Assay Detail
Binding
CHEMBL2433674
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Inhibition of LPS-induced NF-kappaB (unknown origin) activation transfected in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS challenge measured after 4 hrs by luciferase reporter gene assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Meroterpenoids with diverse ring systems from the sponge-associated fungus Alternaria sp. JJY-32.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.33 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1449651 | PYRROLIDINE DITHIOCARBAMIC ACID, AMMONIUM SALT | — | 1 | 5.52 |
| CHEMBL2431888 | — | — | 1 | 4.41 |
| CHEMBL2431876 | — | — | 1 | 4.38 |
| CHEMBL2431889 | (+)-MONOCYCLOALTERNARENE A | — | 1 | 4.35 |
| CHEMBL2431890 | (+)-MONOCYCLOALTERNARENE B | — | 1 | 4.33 |
| CHEMBL2431887 | — | — | 1 | 4.30 |
| CHEMBL2431878 | TRICYCLOALTERNARENE A | — | 1 | 4.28 |
| CHEMBL2431877 | — | — | 1 | 4.24 |
| CHEMBL2431879 | — | — | 1 | 4.21 |
| CHEMBL2431881 | — | — | 1 | 4.17 |
| CHEMBL2431880 | — | — | 1 | 4.16 |
| CHEMBL2431886 | TRICYCLOALTERNARENE C | — | 1 | 4.12 |
| CHEMBL2431885 | TRICYCLOALTERNARENE B | — | 1 | 4.12 |
| CHEMBL2431882 | — | — | 1 | 4.07 |
| CHEMBL2431884 | — | — | 1 | - |
| CHEMBL2431883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1449651 | PYRROLIDINE DITHIOCARBAMIC ACID, AMMONIUM SALT | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2431888 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL2431876 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2431889 | (+)-MONOCYCLOALTERNARENE A | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2431890 | (+)-MONOCYCLOALTERNARENE B | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL2431887 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2431878 | TRICYCLOALTERNARENE A | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL2431877 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL2431879 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL2431881 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL2431880 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2431886 | TRICYCLOALTERNARENE C | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL2431885 | TRICYCLOALTERNARENE B | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL2431882 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL2431884 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2431883 | — | IC50 | > | 100000.0 | nM | - |