Assay Detail
Binding
CHEMBL2433710
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Inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.86 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2430707 | — | — | 1 | 8.54 |
| CHEMBL2430706 | — | — | 1 | 8.21 |
| CHEMBL145059 | — | — | 1 | 7.42 |
| CHEMBL2430703 | — | — | 1 | 7.07 |
| CHEMBL2430709 | — | — | 1 | 6.89 |
| CHEMBL2430708 | — | — | 1 | 6.72 |
| CHEMBL2430705 | — | — | 1 | 6.55 |
| CHEMBL2430702 | — | — | 1 | 6.21 |
| CHEMBL2430704 | — | — | 1 | 5.63 |
| CHEMBL172856 | — | — | 1 | 5.40 |
| CHEMBL2430710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2430707 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2430706 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL145059 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2430703 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2430709 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2430708 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL2430705 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL2430702 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2430704 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL172856 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL2430710 | — | IC50 | = | 201000.0 | nM | - |