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Assay Detail

CHEMBL2434041

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against chloroquine-resistant blood stage forms of Plasmodium falciparum Dd2 after 3 days by HRP2-based ELISA
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
Kunfermann A, Lienau C, Illarionov B, Held J, Gräwert T, Behrendt CT, Werner P, Hähn S, Eisenreich W, Riederer U, Mordmüller B, Bacher A, Fischer M, Groll M, Kurz T.
J Med Chem (2013) 56 : 8151 -8162
PubMed 24032981 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.68 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1830118 1 7.40
CHEMBL1830114 1 7.19
CHEMBL2164255 1 7.13
CHEMBL2431006 1 7.12
CHEMBL2431008 1 7.07
CHEMBL2431007 1 7.06
CHEMBL2431010 1 7.02
CHEMBL2164262 1 6.89
CHEMBL2164263 1 6.85
CHEMBL2164264 1 6.72
CHEMBL2431012 1 6.48
CHEMBL2164259 1 6.46
CHEMBL2431009 1 6.29
CHEMBL2431005 1 6.24
CHEMBL2164258 1 6.16
CHEMBL2431013 1 6.06
CHEMBL2431011 1 5.42
CHEMBL2164266 1 -
CHEMBL2431014 1 -
CHEMBL1830119 1 -
CHEMBL1830117 1 -
CHEMBL2164256 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1830118 IC50 = 40.0 nM 7.40
CHEMBL1830114 IC50 = 65.0 nM 7.19
CHEMBL2164255 IC50 = 74.0 nM 7.13
CHEMBL2431006 IC50 = 75.0 nM 7.12
CHEMBL2431008 IC50 = 85.0 nM 7.07
CHEMBL2431007 IC50 = 88.0 nM 7.06
CHEMBL2431010 IC50 = 95.0 nM 7.02
CHEMBL2164262 IC50 = 130.0 nM 6.89
CHEMBL2164263 IC50 = 140.0 nM 6.85
CHEMBL2164264 IC50 = 190.0 nM 6.72
CHEMBL2431012 IC50 = 330.0 nM 6.48
CHEMBL2164259 IC50 = 350.0 nM 6.46
CHEMBL2431009 IC50 = 510.0 nM 6.29
CHEMBL2431005 IC50 = 570.0 nM 6.24
CHEMBL2164258 IC50 = 700.0 nM 6.16
CHEMBL2431013 IC50 = 870.0 nM 6.06
CHEMBL2431011 IC50 = 3770.0 nM 5.42
CHEMBL2164266 IC50 - -
CHEMBL2431014 IC50 - -
CHEMBL1830119 IC50 - -
CHEMBL1830117 IC50 - -
CHEMBL2164256 IC50 - -