Assay Detail
Binding
CHEMBL2434052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured after 18 hrs by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.41 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089842 | — | — | 1 | 6.01 |
| CHEMBL2431028 | — | — | 1 | 5.37 |
| CHEMBL2431027 | — | — | 1 | 5.25 |
| CHEMBL2431026 | — | — | 1 | 5.02 |
| CHEMBL2431021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089842 | — | IC50 | = | 966.0 | nM | 6.01 |
| CHEMBL2431028 | — | IC50 | = | 4272.0 | nM | 5.37 |
| CHEMBL2431027 | — | IC50 | = | 5641.0 | nM | 5.25 |
| CHEMBL2431026 | — | IC50 | = | 9519.0 | nM | 5.02 |
| CHEMBL2431021 | — | IC50 | > | 10000.0 | nM | - |