Assay Detail
Binding
CHEMBL2434151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha-induced nuclear factor-kappa-B activation in human HEK293 cells at by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.78 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2430197 | — | — | 1 | 6.28 |
| CHEMBL2430196 | — | — | 1 | 5.65 |
| CHEMBL60718 | TPCK | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2430197 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2430196 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL60718 | TPCK | IC50 | = | 3800.0 | nM | 5.42 |