Assay Detail
Binding
CHEMBL2434267
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Displacement of [123I]-DCIT from PSMA in human LNCaP cells after 1 hr by gamma counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation of asymmetric urea derivatives that target prostate-specific membrane antigen for SPECT imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.87 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431341 | — | — | 1 | 8.67 |
| CHEMBL2431330 | — | — | 1 | 8.55 |
| CHEMBL2431340 | — | — | 1 | 8.53 |
| CHEMBL2431336 | — | — | 1 | 8.30 |
| CHEMBL2431339 | — | — | 1 | 8.20 |
| CHEMBL2431338 | — | — | 1 | 8.10 |
| CHEMBL2431337 | — | — | 1 | 8.09 |
| CHEMBL47009 | — | — | 1 | 7.51 |
| CHEMBL2431331 | — | — | 1 | 7.21 |
| CHEMBL2431332 | — | — | 1 | 7.02 |
| CHEMBL103512 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431341 | — | Ki | = | 2.14 | nM | 8.67 |
| CHEMBL2431330 | — | Ki | = | 2.79 | nM | 8.55 |
| CHEMBL2431340 | — | Ki | = | 2.95 | nM | 8.53 |
| CHEMBL2431336 | — | Ki | = | 4.97 | nM | 8.30 |
| CHEMBL2431339 | — | Ki | = | 6.26 | nM | 8.20 |
| CHEMBL2431338 | — | Ki | = | 7.91 | nM | 8.10 |
| CHEMBL2431337 | — | Ki | = | 8.06 | nM | 8.09 |
| CHEMBL47009 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL2431331 | — | Ki | = | 62.1 | nM | 7.21 |
| CHEMBL2431332 | — | Ki | = | 94.8 | nM | 7.02 |
| CHEMBL103512 | — | Ki | = | 376.0 | nM | 6.42 |