Assay Detail
Binding
CHEMBL2434414
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Binding affinity to I2 imidazoline binding site in rat brain membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.20 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404505 | — | — | 1 | 8.89 |
| CHEMBL14107 | — | — | 1 | 8.88 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 8.35 |
| CHEMBL13917 | — | — | 1 | 8.25 |
| CHEMBL2431279 | — | — | 1 | 7.90 |
| CHEMBL2431281 | — | — | 1 | 6.90 |
| CHEMBL2431280 | — | — | 1 | - |
| CHEMBL1956197 | — | — | 1 | - |
| CHEMBL1956192 | — | — | 1 | - |
| CHEMBL2431282 | — | — | 1 | - |
| CHEMBL1276218 | — | — | 1 | - |
| CHEMBL1956195 | CYCLOMETHYLINE | — | 1 | - |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404505 | — | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL14107 | — | Ki | = | 1.318 | nM | 8.88 |
| CHEMBL13852 | CIRAZOLINE | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL13917 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL2431279 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL2431281 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL2431280 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1956197 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1956192 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2431282 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1276218 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1956195 | CYCLOMETHYLINE | Ki | > | 1000.0 | nM | - |
| CHEMBL495095 | ALLYPHENYLINE | Ki | > | 1000.0 | nM | - |