Assay Detail
ADMET
CHEMBL2434458
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Cytotoxicity against human PrEC assessed as growth inhibition after 48 hrs by trypan blue exclusion assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PrEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New route for synthesis, spectroscopy, and X-ray studies of 2-[aryl-(6-hydroxy-4,4-dimethyl-2-oxocyclohex-6-enyl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-enone and 1,8-dioxo-octahydroxanthenes and antitumor evaluation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI | 3 | - | - |
| IC50 | 3 | 6.24 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2429903 | — | — | 2 | 6.48 |
| CHEMBL1348027 | — | — | 2 | 6.35 |
| CHEMBL2429902 | — | — | 2 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2429903 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1348027 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2429902 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL1348027 | — | GI | - | — | - | |
| CHEMBL2429903 | — | GI | - | — | - | |
| CHEMBL2429902 | — | GI | - | — | - |