Assay Detail
Functional
CHEMBL2434460
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SF268 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SF-268 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New route for synthesis, spectroscopy, and X-ray studies of 2-[aryl-(6-hydroxy-4,4-dimethyl-2-oxocyclohex-6-enyl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-enone and 1,8-dioxo-octahydroxanthenes and antitumor evaluation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.68 | 7.70 |
| GI | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2429902 | — | — | 2 | 7.70 |
| CHEMBL2429903 | — | — | 2 | 7.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.05 |
| CHEMBL1348027 | — | — | 2 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2429902 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2429903 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1348027 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL1348027 | — | GI | - | — | - | |
| CHEMBL2429903 | — | GI | - | — | - | |
| CHEMBL2429902 | — | GI | - | — | - |